*{ margin: 0; padding: 0; box-sizing: border-box; }

img{ max-width: 100%; height: auto; }
svg { width: 25px; height: 25px; }

.article_time img { width: 20px; }
span.title-icon img { width: 20px; }
.arrow img { width: 20px; }
.doc-icon img { width: 20px; }
.icon img { width: 25px; }

span.icon { width: 50px; height: 50px; background-color: #E0EAF5; border-radius: 8px; display: flex; align-items: center; justify-content: center; }

.article_container a, .article_container p, .article_container ul, .article_container li,  .article_container span { color: #6A6E71; font-family: "Aspekta 400 Regular";}
.article_container h1, .article_container h2, .article_container h3, .article_container h4, .article_container h5, .article_container h6{ color: #10131C; }

section.article_top_sec { padding: 160px 0 60px 0; }
.article_container { max-width: 1296px; width: 100%; margin: 0 auto; padding: 0 20px;}
.bread_crump_wrp ul { list-style: none; display: flex; gap: 20px; }
.bread_crump_wrp ul li:last-child a { color: #000; }
.regulatory_btn span { background-color: #E0EAF5; padding: 5px 10px; border-radius: 5px; font-size: 16px; display: inline-flex; color: #0E68BD; }
.article_min_heading h1 { font-size: 60px; font-weight: 600; line-height: 120%; margin: 0; letter-spacing: 0.5px;}
.article_date span { font-size: 18px; color: #6A6E71; }
.article_time svg { height: 20px; width: 20px; }
.article_time { display: flex; gap: 50px; }
.date_icon_wrp span { display: flex; }
.date_icon_wrp { display: flex; gap: 12px; align-items: center; }
.article_mainimg_wrp { padding: 30px; background-color: #E0EAF5; border-radius: 20px; }
.article_mainimg_wrp img { border-radius: 20px; width: 100%; display: flex; height: auto; }
.article_top_sec .article_container { display: flex; flex-direction: column; row-gap: 25px; }
.date_time_main { display: flex; flex-direction: column; row-gap: 20px; }

.article_summary_otr { padding: 30px; background: #F5F7FB; border-radius: 15px; border: 1px solid#ccc; }
.article_summary_otr .card { display: flex; flex-direction: column; row-gap: 20px; }
.article_summary_otr ul { display: flex; flex-direction: column; row-gap: 15px;  list-style: none; }
.article_summary_otr ul li { font-size: 18px; color: #484848; line-height: 130%; position: relative; display: flex; column-gap: 12px; align-items: flex-start; }
.article_summary_otr .card-header { display: flex; justify-content: space-between; }
.article_summary_otr .title { display: flex; gap: 12px; font-size: 20px; font-weight: 600; }
.article_summary_otr .title span.title-icon { display: flex; }
section.keyTakeway_otr { padding: 60px 0;  border-top: 1px solid #c1c1c1;}
.article_summary_otr ul li:before { content: ''; height: 8px; min-width: 8px; background-color: #0E68BD; display: inline-flex; border-radius: 100%; top: 6px; position: relative; }
.article_summary_otr .summary { font-size: 18px; color: #646464; font-weight: 500; }

.article_container p { font-size: 20px; line-height: 180%; }
.article_container h2 { font-size: 34px; line-height: 130%; margin: 0; font-weight: 600; margin-bottom: 20px; letter-spacing: 0.6px;}
.article_container  h3 { font-size: 26px; font-weight: 600; letter-spacing: 0.6px; margin: 0;}
.keyTakeway_otr .article_container { display: flex; flex-direction: column; row-gap: 25px; }
.content_keyeway_wrp { display: flex; flex-direction: column; row-gap: 20px; }
.small_paragraph p { color: #888d91; font-size: 19px; }

.where_to_getDocument_wrp { display: flex; flex-direction: column; row-gap: 20px; }
.where_to_getDocument_wrp > .ducument_sub_heading h2 { margin: 0; }
.article_container  .no_sapce { margin: 0; }
span.blue_text { color: #0E68BD; }

/* accordion */
.accordion-main-outer .accordion-item { background: #ffffff; border-radius: 12px; box-shadow: 0 0 10px 0px rgb(0 0 0 / 4%); overflow: hidden; }
.accordion-main-outer .accordion-header { display: flex; align-items: center; justify-content: space-between; padding: 18px 20px; cursor: pointer; background: #EDF3FB; }
.accordion-main-outer .accordion-title { display: flex; align-items: center; gap: 12px; font-size: 22px; font-weight: 600; color: #000; letter-spacing: 0.5px; }
.accordion-main-outer .icon { width: 50px; height: 50px; background: #E0EAF5; border-radius: 8px; display: flex; align-items: center; justify-content: center; }
.accordion-main-outer .arrow { transition: transform 0.3s ease; }
.accordion-main-outer .accordion-item.active .arrow { transform: rotate(180deg); }
.accordion-main-outer .accordion-content { overflow: hidden; transition: 0.4s ease; padding: 0 20px; height: 0; display: flex; flex-direction: column; row-gap: 20px; }
.accordion-main-outer .accordion-item.active .accordion-content { padding: 20px; height: auto; }
.article_container p strong { color: #000; letter-spacing: 0.5px; }
.accordion-main-outer .card { background-color: #EDF3FB; border-radius: 10px; padding: 15px; display: flex; flex-direction: column; row-gap: 15px; }
.accordion-main-outer .card h4 { margin: 0; font-size: 20px; font-weight: bold; letter-spacing: 0.5px; }
.accordion-main-outer .doc { display: flex; align-items: center; gap: 10px; margin: 0; color: #444; font-size: 16px; }
.doc-icon svg { width: 20px; height: 20px; }
.clinical_investgations-heading { display: flex; gap: 20px; }
.clinical_investgations-top-box { display: flex; flex-direction: column; row-gap: 20px; }
.clinical_investgations_toboxes-wrp { display: flex; gap: 30px; justify-content: space-between; }
.clinical_investgations-bottom-box { display: flex; flex-direction: column; row-gap: 15px; background: #F7F9FB; padding: 20px; border-radius: 10px; border: 1px solid #c1c1c1; width: calc(50% - 15px); }

.with-out_icon_wrp { display: flex; flex-direction: column; row-gap: 20px; }
.with-out_icon_wrp h2 { font-size: 24px; margin: 0; }
.with-out_icon_wrp p { font-size: 18px; }


/* leatest_articles */

.leatest_articles_main-otr .articles-one { background-color: #F7F9FB; border: 1px solid #e5e7eb; border-radius: 15px; padding: 20px; color: #374151; width: calc(33.33% - 20px); display: flex; flex-direction: column; row-gap: 12px; }
.leatest_articles_main-otr .title { font-size: 18px; font-weight: 600; color: #000; letter-spacing: 0.6px; }
.leatest_articles_main-otr .subtitle { font-size: 16px; color: #6A6E71; }
.articles-one .date { font-size: 16px; color: #6A6E71; }

  .leatest_articles_main-otr .row { display: flex; align-items: center; font-size: 15px; color: #4b5563; margin-bottom: 10px; }
.leatest_articles_main-otr .icon { width: 18px; height: 18px; margin-right: 10px; fill: #9ca3af; }
.leatest_articles_main-otr .address { margin-top: 10px; font-size: 15px; color: #4b5563; line-height: 1.5; }



.leatest_articles_main-otr .articles { display: flex; gap: 20px; flex-wrap: wrap; }
.leatest_articles_main-otr .image-placeholder img { border-radius: 10px; }
.byterocket-main-outer .byterocket-wrp { background-color: #F7F9FB; border: 1px solid #e5e7eb; border-radius: 15px; padding: 30px; color: #374151; display: flex; flex-direction: column; row-gap: 10px; }
.byterocket-wrp div { font-size: 18px; color: #6A6E71; line-height: 150%; }
.byterocket-main-outer .byterocket-wrp .row:after, .byterocket-main-outer .byterocket-wrp .row:before { display: none; }
.byterocket-wrp .row img { width: 20px; }
.byterocket-main-outer .byterocket-wrp .row { display: flex; margin: 0; gap: 12px; }
section.leatest-articles_sec { padding: 60px 0; border-top: 1px solid #c1c1c1 }
.leatest-articles_sec .article_container { display: flex; flex-direction: column; row-gap: 40px; }
.byterocket-wrp .title { font-size: 20px; font-weight: 600; color: #000; }
.clinical_investgations_otr { display: flex; flex-direction: column; row-gap: 25px; }
.accordion-main-outer { margin: 20px 0 10px 0; }
.with-out_icon_wrp-top.clinical_investgations-bottom-box { width: 100%; }
.clinical_investgations-top-box h2 { margin: 0; }
.clinical_investgations-top-box { margin-top: 30px; }
.mdr_guidance-wrp { display: flex; flex-direction: column; row-gap: 10px; }
.mdr_guidance-wrp h2 { margin: 0; }
.content_keyeway_wrp { row-gap: 10px; }


@media (max-width:1366px){
    .article_min_heading h1 { font-size: 50px; }
    .article_top_sec .article_container { row-gap: 20px; }
    .article_container h2 { font-size: 30px; }
    .where_to_getDocument_wrp { row-gap: 15px; }
    .clinical_investgations-top-box { margin-top: 25px; }
    .leatest-articles_sec .article_container { row-gap: 30px; }

    span.doc-icon { min-width: 20px; }
}

@media(max-width:1200px){
    section.article_top_sec { padding: 140px 0 60px 0; }
    span.icon { min-width: 40px; min-height: 40px; }
    .icon img { width: 20px; }
    .article_container h2 { font-size: 26px; }
}

@media(max-width:991px){
    .leatest_articles_main-otr .articles-one { width: calc(50% - 10px); }
    .page-template-temp-article main#main { padding: 0 !important; }
}
@media(max-width:767px){
    .page-template-temp-article main#main { padding: 0 !important; }
    section.article_top_sec { padding: 100px 0 50px 0; }
    .article_top_sec .article_container { row-gap: 15px; }
    .article_min_heading h1 { font-size: 26px !important; }.article_date span { font-size: 16px; }
    .date_time_main { row-gap: 15px; }
    .article_time {  gap: 30px; }
    .article_mainimg_wrp { padding: 20px; border-radius: 15px; }
    .article_mainimg_wrp img { border-radius: 15px; }
    section.keyTakeway_otr { padding: 50px 0; }
    .article_summary_otr { padding: 20px; border-radius: 15px; }
    .article_summary_otr ul { row-gap: 10px; }
    .article_summary_otr .title { font-size: 18px; margin: 0;}
    .article_container p { font-size: 18px; }
    .content_keyeway_wrp { row-gap: 15px; }
    .keyTakeway_otr .article_container { row-gap: 20px; }
    .article_container h2 { font-size: 24px !important; }
    .article_container  h3 { font-size: 22px !important; }
    .accordion-main-outer .accordion-content { row-gap: 15px; }
    .clinical_investgations-top-box { row-gap: 15px; }
    .clinical_investgations-top-box { margin-top: 15px; }
    .byterocket-main-outer .byterocket-wrp { padding: 20px; }
    .clinical_investgations-bottom-box { width: 100%; }
    .clinical_investgations_toboxes-wrp { flex-direction: column; gap: 15px; }
    .leatest_articles_main-otr .title{ margin: 0; }
    section.leatest-articles_sec{ padding: 50px 0; }
    .accordion-main-outer .accordion-title{ font-size: 20px; }
}
@media(max-width:575px){
    .leatest_articles_main-otr .articles-one { width: 100%; }
    .leatest_articles_main-otr .articles { gap: 15px; }
}